Fansidar in malaria prophylaxis.

Quinine Prophylaxis in Malaria

In the effect of quinine on the malarial parasite we have perhaps the most remarkable example of the specific action of a drug in the whole range of medicine and one which has stood the test of two and a half centuries. Yet we have the apparent paradox of the frequently reported failure of the drug prophylactically against malaria. It is abundantly proved that when a primary infection of malari...

Malaria prophylaxis for travellers.

Prophylaxis of Malaria

Malaria prevention in travelers to endemic areas remains dependent principally on chemoprophylaxis. Although malaria chemoprophylaxis refers to all malaria species, a distinction should be drawn between falciparum malaria prophylaxis and the prophylaxis of the relapsing malaria species (vivax & ovale). While the emergence of drug resistant strains, as well as the costs and adverse reactions to ...

Tolerability of long-term prophylaxis with fansidar: a randomized double-blind study in Nigeria.

A randomized double-blind study was performed to compare the side effects of long-term chemoprophylaxis of malaria with Fansidar (1 tablet a week) with those of a 300-mg weekly chloroquine regimen. This study was designed as a field trial with Austrian industrial workers in Nigeria and included 173 volunteers, 86 taking Fansidar and 87 taking chloroquine for 6 to 22 months. Only a few complaint...

Malaria Prophylaxis: A Comprehensive Review

The flow of international travellers to and from malaria-endemic areas, especially Africa, has increased in recent years. Apart from the very high morbidity and mortality burden imposed on malaria-endemic areas, imported malaria is the main cause of fever possibly causing severe disease and death in travellers coming from tropical and subtropical areas, particularly Sub-Saharan Africa. The impo...